反应详情

Tetraethyl (phenoxymethylene)-bisphosphonate (1.14 g) was added to a suspension of 55% sodium hydride (0.15 g) in dimethylformamide (10 ml). After 45 minutes at room temperature, ethyl iodide (0.49 ml) was added, and the mixture was left overnight at room temperature, diluted with ethyl acetate and washed with 40% aqueous calcium chloride. The organic phase was dried and evaporated to leave an oil which was purified by chromatography on silica gel. The title compound was isolated as a colourless oil.

1. waitthe mixture was left overnight at room temperature
2. washwashed with 40% aqueous calcium chloride
3. customThe organic phase was dried
4. customevaporated
5. customto leave an oil which
6. customwas purified by chromatography on silica gel