Diisopropylcarbodiimide → HCID 86659418, compound

HRID 572142Notes

Reaction equation

HRID 572142 reaction equation
CC(C)[N:3]=[C:4]=[N:5]C(C)C.CCN=C=NCCCN(C)C.[CH:21]1[CH:22]=[CH:23][C:24]2[N:29]([OH:30])[N:28]=[N:27][C:25]=2[CH:26]=1>CN(C=O)C>[NH:3]=[C:4]=[NH:5].[CH:21]1[CH:22]=[CH:23][C:24]2[N:29]([OH:30])[N:28]=[N:27][C:25]=2[CH:26]=1

Participants

5

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-Hydroxybenzotriazole

Product 1

HCID 86659418HCID 86659418, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a suspension of compound AE or AM′ (1.0 equiv.) in DMF, DIC (1.5 equiv.) or EDCI (1.5 equiv.), HOBt (1.5 equiv.) and the selected amine (1.5-5.0 equiv.) were added. The mixture was stirred at R.T. for 12-72 Hrs or heated through microwave irradiation for 5 min at 150° C.

Workup

  1. temperatureheated through microwave irradiation for 5 min at 150° C.

Sources & evidence

ORD record
ord-65e6d132dce74b45a46e9893fbfe10ce
Source dataset
uspto-grants-2015_05
Patent number
US09029393B2

Reaction notes

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