反应详情

Ethyl 2-chloroimidazo[1,2-a]pyridine-3-carboxylate (2.00 g) was added to a solution of p-bromophenol (1.617 g) and NaH (0.427 g) in DMF (10 mL) at 100° C. The mixture was stirred at 100° C. under a dry atmosphere (CaCl2 tube) overnight. The reaction mixture was diluted with MeOH, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (530 mg).

1. concentrationconcentrated under reduced pressure
2. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)