反应详情

Acid 15-3 (300 mg, 0.91 mmol), amine 2-1 (325 mg, 0.91 mmol), EDC (209 mg, 1.09 mmol), HOBT (148 mg, 1.10 mmol), and NMM (300 μL, 2.7 mmol) were combined in 4.5 mL DMF. After 16 h the mixture was diluted with EtOAc, washed with water, 10% KHSO4, sat NaHCO3, and brine, dried (MgSO4), and concentrated. Flash chromatography (silica, 70% EtOAc/hexane) provided 15-4 as an off-white solid.

1. washwashed with water, 10% KHSO4
2. dry with materialdried (MgSO4)
3. concentrationconcentrated