反应详情

1.4 g (59 mmol) of magnesium turnings are placed in tetrahydrofuran in a round-bottomed flask and under a stream of nitrogen. 13.2 g (54 mmol) of 2-bromo-4-ethoxymethoxy-1-methylbenzene diluted in a small amount of THF are added slowly. The medium is refluxed for 20 minutes. It is then added via a cannula to 15 ml (65 mmol) of triisopropyl borate. The mixture sets to a solid and is then poured into 1N hydrochloric acid solution and extracted with ether. The organic phase is dried over magnesium sulfate, filtered and then evaporated. 9.8 g (87%) of the expected product are obtained in the form of a brown oil.

1. additionare added slowly
2. temperatureThe medium is refluxed for 20 minutes
3. extractionextracted with ether
4. dry with materialThe organic phase is dried over magnesium sulfate
5. filtrationfiltered
6. customevaporated