Trifluoroacetic acid → HCID 117701066, compound

Temperature

90 °C

1-Hydroxybenzotriazole monohydrate (574 mg, 3.75 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (1.44 g, 7.49 mmol) were added to an N,N-dimethylformamide (20 mL) solution of the compound obtained in Reference Example 80 (900 mg, 3.75 mmol) at room temperature, and the mixture was stirred at the same temperature for 30 minutes. The compound obtained in Reference Example 83 (930 mg, 3.75 mmol) was added to the mixture at room temperature, and the resulting mixture was stirred at room temperature for 20 minutes, and then heated at 90° C. for 6 hours. After the reaction mixture was cooled to room temperature, water and a saturated aqueous solution of sodium hydrogen carbonate were added to the reaction mixture. The resulting mixture was extracted three times with ethyl acetate. The organic layer thus obtained was washed with a 10% aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1-41:1, v/v) to give a mixture containing tert-butyl 4-(3-{1-[4-(cyclopropylcarbonyl)phenoxy]ethyl}-1,2,4-oxadiazol-5-yl)-2-fluorobenzoate. Subsequently, a methylene chloride (2 mL) solution of trifluoroacetic acid (2 mL) was added to a methylene chloride (4 mL) solution of the mixture thus obtained at room temperature, and the resulting mixture was stirred at the same temperature for 30 minutes. Trifluoroacetic acid (2 mL) was added to the mixture at room temperature, and the resulting mixture was stirred at the same temperature for 20 minutes. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1→1:4, v/v) to give the title compound (655 mg, yield: 44%).

1. additionwas added to the mixture at room temperature
2. stirringthe resulting mixture was stirred at room temperature for 20 minutes
3. temperatureAfter the reaction mixture was cooled to room temperature
4. extractionThe resulting mixture was extracted three times with ethyl acetate
5. customThe organic layer thus obtained
6. washwas washed with a 10% aqueous solution of sodium chloride
7. dry with materialdried over anhydrous sodium sulfate
8. distillationThe solvent was distilled off under reduced pressure
9. customthe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1-41:1, v/v)
10. customto give a mixture
11. customthus obtained at room temperature
12. stirringthe resulting mixture was stirred at the same temperature for 30 minutes
13. stirringthe resulting mixture was stirred at the same temperature for 20 minutes
14. distillationThe solvent was distilled off under reduced pressure
15. customthe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1→1:4, v/v)

ORD record

ord-25abc09d67fd46db814e658193e9e715

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09233958B2