1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 118656288, compound

HRID 591543Notes

Reaction equation

HRID 591543 reaction equation
[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[CH:17]=[CH:16][C:9]2[CH:10]([C:13](O)=[O:14])[CH2:11][O:12][C:8]=2[CH:7]=1.[CH3:23][S:24]([NH2:27])(=[O:26])=[O:25].CCN=C=NCCCN(C)C>CN(C=O)C.CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[CH:17]=[CH:16][C:9]2[CH:10]([C:13]([NH:27][S:24]([CH3:23])(=[O:26])=[O:25])=[O:14])[CH2:11][O:12][C:8]=2[CH:7]=1

Participants

6

Reactant 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 72879MethanesulfonamideHCID 118656238HCID 118656238, compound

Product 1

HCID 118656288HCID 118656288, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6228DimethylformamideSolvent

Procedure

To a mixture of 6-((2,4-dichlorobenzyl)oxy)-2,3-dihydro-1-benzofuran-3-carboxylic acid (120 mg) in DMF (dry) (3.5 mL) were added methanesulfonamide (101 mg), EDCI (203 mg) and DMAP (130 mg). The mixture was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-1e7a4204417247bd8643484ef4ad5cab
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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