反应详情

温度

-78 °C

Add a 2 M solution of n-butyllithium in hexanes (63 mL, 157.5 mmol) to a −20° C. solution of 2,2,6,6-tetramethylpiperidine (28 mL, 165 mmol) in tetrahydrofuran (400 μL). Cool to −78° C. and add 1-iodo-4-fluorobenzene (17.3 mL, 150 mmol) dropwise over 10 min. Stir the reaction mixture at −78° C. for 3 h and add triisopropylborate (40 mL, 172.5 mmol) dropwise over 20 min. Stir for another 30 min and warm the reaction to 40° C. and add of 5 N hydrochloric acid (75 mL). Partition the reaction mixture between diethyl ether (500 mL) and add 1 N hydrochloric acid (500 mL). Separate the organic layer and extract with 2 N sodium hydroxide (400 mL). Make the aqueous layer slightly acidic (pH ˜5-6) by dropwise addition of 5 N hydrochloric acid and collect the resulting white precipitate by filtration. Dry the precipitate overnight under vacuum to provide 2-fluoro-5-iodophenylboronic acid as a white solid, which is used directly without further purification (39g, 98%).

1. stirringStir for another 30 min
2. temperaturewarm
3. customthe reaction to 40° C.
4. customPartition the reaction mixture between diethyl ether (500 mL)
5. additionadd 1 N hydrochloric acid (500 mL)
6. customSeparate the organic layer
7. extractionextract with 2 N sodium hydroxide (400 mL)
8. additionby dropwise addition of 5 N hydrochloric acid
9. customcollect the resulting white precipitate
10. filtrationby filtration
11. customDry the precipitate overnight under vacuum