反应详情

温度

100 °C

In a three-neck flask, methyl 6-(phenylamino)hexanoate (25.0 g, 0.113 mmol) and potassium carbonate (25.0 g, 0.169 mol) were added to dimethylformamide (100 ml) and stirred. The mixture was heated to 100° C., added with 3-(bromomethyl)heptane (26.2 g, 0.135 mol), and allowed to react with stirring for 12 hours. The reaction product was transferred into a separate funnel, and was then added with water and ethyl acetate, after which the organic layer was isolated therefrom, dehydrated using sodium sulfate, and then distilled under reduced pressure. Subsequently, the obtained material was separated through silica column chromatography, thus obtaining 20.0 g of a yellowish transparent liquid.

1. customto react
2. stirringwith stirring for 12 hours
3. customThe reaction product was transferred into a separate funnel
4. customafter which the organic layer was isolated
5. distillationdistilled under reduced pressure
6. customSubsequently, the obtained material was separated through silica column chromatography