Potassium Carbonate → HCID 21846928, compound

HRID 619751Notes

Reaction equation

HRID 619751 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].[NH2:18][C:19]1[C:24]([N+:25]([O-:27])=[O:26])=[CH:23][CH:22]=[C:21](Cl)[N:20]=1>CN(C=O)C>[CH:1]1[C:10]2[C:5](=[C:6]([S:11][C:21]3[N:20]=[C:19]([NH2:18])[C:24]([N+:25]([O-:27])=[O:26])=[CH:23][CH:22]=3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27240356-Chloro-3-nitropyridin-2-ylamineHCID 110519635-Isoquinolinethiol

Product 1

HCID 21846928HCID 21846928, compoundYield 86.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to the method in Example 10, a mixture of 5-isoquinolinethiol 300 mg (1.9 mmol), DMF 10 ml, potassium carbonate 520 mg (3.7 mmol) and 2-amino-6-chloro-3-nitropyridine 300 mg (1.9 mmol) was stirred at room temperature for 30 minutes, and 6-(5-isoquinolylsulfanyl)-3-nitro-2-pyridylamine 460 mg (86.7%) was obtained.

Sources & evidence

ORD record
ord-82216d9211f544509ded7c5866f0614c
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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