Dabco → 1-(2-Chloropyridin-4-yl)-3-isopropylurea

HRID 619876Notes

Reaction equation

HRID 619876 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([Cl:8])[CH:3]=1.N12CCN(CC1)CC2.[CH3:17][CH:18]([N:20]=[C:21]=[O:22])[CH3:19]>CN(C)C=O>[Cl:8][C:4]1[CH:3]=[C:2]([NH:1][C:21]([NH:20][CH:18]([CH3:19])[CH3:17])=[O:22])[CH:7]=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 9237DabcoHCID 61277Isopropyl isocyanateHCID 844322-Chloropyridin-4-amine

Product 1

HCID 144571721-(2-Chloropyridin-4-yl)-3-isopropylurea

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2.6 grams (0.0203 mole) of 4-amino-2-chloropyridine, 0.53 gram (0.005 mole) of 1,4-diazabicyclo[2.2.2]octane (DABCO), and 3.9 ml (0.0305 mole) of (1-methylethyl)isocyanate in 20 ml of dry dimethylformamide was stirred at ambient temperature for five days. The dimethylformamide was removed under reduced pressure. The residue was taken up in 20 ml of ethanol and this was removed under reduced pressure. The procedure was repeated a second time using an additional 20 ml of ethanol. The residual oil was dried under reduced pressure at ambient temperature for 16 hours, then under reduced pressure at 60° C. for one hour. The resultant solid was triturated in hot water. The mixture was allowed to cool to ambient temperature then placed in a refrigerator where it stood for 60 hours. The solid was collected by filtration, washed with water and dried under reduced pressure for three hours at 40°-50° C. The yield of N-(2-chloro-4-pyridinyl)-N'-(1-methylethyl)urea was 4.1 grams, m.p. 142°-146.5° C. The nmr spectrum was consistent with the proposed structure.

Workup

  1. customThe dimethylformamide was removed under reduced pressure
  2. customthis was removed under reduced pressure
  3. customThe residual oil was dried under reduced pressure at ambient temperature for 16 hours
  4. customThe resultant solid was triturated in hot water
  5. waitstood for 60 hours
  6. filtrationThe solid was collected by filtration
  7. washwashed with water
  8. customdried under reduced pressure for three hours at 40°-50° C

Sources & evidence

ORD record
ord-c24124b717604a6b8b67118195511de5
Source dataset
uspto-grants-1989_04
Patent number
US04818271

Reaction notes

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