Acetone → HCID 14407713, compound

HRID 620124Notes

Reaction equation

HRID 620124 reaction equation
[OH-].[Na+].[OH:3][CH2:4][C:5]1[CH:6]=[C:7]([NH:11][N:12]=[C:13]2[C:17](=[O:18])[O:16][C:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:14]2)[CH:8]=[CH:9][CH:10]=1.CC(C)=O.Cl>C(C(C)=O)C.CN(C)C=O.O1CCCC1.O1CCOCC1>[OH:3][CH2:4][C:5]1[CH:6]=[C:7]([N:11]2[C:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:14][C:13]([C:17]([OH:16])=[O:18])=[N:12]2)[CH:8]=[CH:9][CH:10]=1

Participants

9

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178519062HCID 178519062, compound

Product 1

HCID 14407713HCID 14407713, compound

Reagents, catalysts & solvents 4

HCID 6228DimethylformamideSolventHCID 6569Methyl Ethyl KetoneSolventHCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

Sodium hydroxide in an amount of more than equivalent is added to the above-mentioned 4-[3-(hydroxymethyl)phenylhydrazono]-2-phenyl-2-oxazolin-5-one in an aprotic organic solvent such as acetone, dioxane, tetrahydrofuran, dimethylformamide and methyl ethyl ketone and after reacting the mixture, hydrochloric acid is added to the mixture to adjust the pH to from 1 to 4, and then the thus adjusted mixture is heated to a temperature of lower than 100° C., preferably from 30° to 60° C., thereby obtaining a novel compound, 1-[3-(hydroxymethyl)phenyl]-5-phenyl-1H-1,2,4,-triazole-3-carboxylic acid represented by the formula (V): ##STR87##

Workup

  1. additionis added to the mixture

Sources & evidence

ORD record
ord-c9870e4431014c1584713ffebf2cf5eb
Source dataset
uspto-grants-1989_04
Patent number
US04820334

Reaction notes

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