Hydrochloric Acid → HCID 67227512, compound

HRID 624339Notes

Reaction equation

HRID 624339 reaction equation
[Cl:1][C:2]1[CH:40]=[CH:39][CH:38]=[CH:37][C:3]=1[O:4][C:5]1[CH:14]=[C:13]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH2:23][O:24][C:25]([CH3:36])([CH3:35])[CH2:26][C:27]=3[C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)[CH2:17][CH2:16]2)[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8].O[Li].O.Cl>O1CCCC1.CO.O.C(OCC)(=O)C>[Cl:1][C:2]1[CH:40]=[CH:39][CH:38]=[CH:37][C:3]=1[O:4][C:5]1[CH:14]=[C:13]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH2:23][O:24][C:25]([CH3:36])([CH3:35])[CH2:26][C:27]=3[C:28]3[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=3)[CH2:17][CH2:16]2)[CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8]

Participants

8

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 67227974HCID 67227974, compound

Product 1

HCID 67227512HCID 67227512, compound

Reagents, catalysts & solvents 4

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of EXAMPLE 38G (254 mg) in tetrahydrofuran (4 mL), methanol (2 mL) and water (2 mL) was added LiOH H2O (126 mg). The mixture was stirred at room temperature overnight. The mixture was then neutralized with 5% aqueous HCl and diluted with ethyl acetate (200 mL). After washing with brine, it was dried over Na2SO4. Filtration and evaporation of solvent gave the product.

Workup

  1. washAfter washing with brine, it
  2. dry with materialwas dried over Na2SO4
  3. filtrationFiltration and evaporation of solvent
  4. customgave the product

Sources & evidence

ORD record
ord-70f1e4b35ffc42a294e5dc2114f9dfdd
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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