反应详情

温度

60 °C

To 1.5 g of (1E,6E)-1-(1H-indol-6-yl)-7-[4-(2-morpholinoethoxy)phenyl]hepta-1,6-diene-3,5-dione were added 13.5 mL of AcOH and 1.31 mL of hydrazine monohydrate, and the mixture was stirred at 60° C. for 3 hours. The reaction mixture was allowed to cool back to room temperature and poured into a stirring mixture of 18.7 g of K2CO3, 95 mL of cold water, 30 mL of AcOEt and 20 mL of THF. The organic layer was separated, washed with saturated brine, dried over MgSO4, and concentrated. The residue was purified by silica gel column chromatography (CHCl3/acetone or CHCl3/methanol system) to give 0.62 g of the title compound (42% yield).

1. temperatureto cool back to room temperature
2. customThe organic layer was separated
3. washwashed with saturated brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (CHCl3/acetone or CHCl3/methanol system)