Dimethylformamide → HCID 59259709, compound

To a solution of 4-hydroxy-1-methylpiperidine (802 mg, 6.96 mmol) in tetrahydrofuran (20 ml) was added sodium hydride (50%, 334 mg, 6.96 mmol) at room temperature, and the mixture was stirred at room temperature for 35 minutes. To the reaction mixture were added a solution of tributyl-iodomethyl-tin (2.00 g, 4.64 mmol) in tetrahydrofuran (5 ml), and N,N-dimethylformamide (10 ml) at room temperature, and the mixture was stirred at room temperature for 7 hours and 50 minutes. To the reaction mixture was added water under ice-cooling, followed by extraction with ethyl acetate. The organic layer was washed sequentially with water and an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. After the solvent was distilled off under reduced pressure, the residue was purified by NH silica gel column chromatography (heptane:ethyl acetate=100:1 to 20:1) to obtain the title compound (1.42 g, 3.39 mmol, 73%).

1. stirringthe mixture was stirred at room temperature for 7 hours and 50 minutes
2. temperaturecooling
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed sequentially with water
5. dry with materialan aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
6. distillationAfter the solvent was distilled off under reduced pressure
7. customthe residue was purified by NH silica gel column chromatography (heptane:ethyl acetate=100:1 to 20:1)

ORD record

ord-582e4e43844c49eb8975369ca4d3d9a1

Source dataset

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07696347B2