Hydrochloric Acid → HCID 20142835, compound

HRID 648622Notes

Reaction equation

HRID 648622 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH2:31])[CH3:27].Cl.N(CC)(CC)CC>C1COCC1>[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH:31][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:27]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 12176Glycine ethyl esterHCID 16757Benzenepentanoic acidHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 20142835HCID 20142835, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Phenylvaleric acid (2.67 g, 15 mmol) in distilled THF was reacted with CDI (15 mmol) followed by glycine ethyl ester.HCl (15 mmol) and (C2H5)3N (15 mmol) as described in Example 35 Part A. The crude material (3.25 g, 82%) was used without purification.

Workup

  1. customThe crude material (3.25 g, 82%) was used without purification

Sources & evidence

ORD record
ord-49b1f8802f494b2cbee06953f26009d3
Source dataset
uspto-grants-1988_04
Patent number
US04735962

Reaction notes

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