Potassium Carbonate → HCID 11979212, compound

HRID 657638Notes

Reaction equation

HRID 657638 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:22]1([CH2:21][CH2:20][CH2:19][O:18][C:15]2[CH:16]=[CH:17][C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:7][CH:8]=3)=[CH:13][CH:14]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 23150304HCID 23150304, compound

Product 1

HCID 11979212HCID 11979212, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the procedure described in example 36, but starting from 1-{3-[4′-(3-chloropropoxy)biphenyl-4-yloxy]propyl}piperidine (250 mg), pyrrolidine (138 mg) and potassium carbonate (360 mg) in N,N-dimethylformamide (2 mL) affords 90 mg of 1-(3-{[4′-(3-piperidinopropoxy)biphenyl-4-yl]oxy}propyl)pyrrolidine as white crystals melting at 105-108° C.

Sources & evidence

ORD record
ord-aace567a9e59414f945e990b908cffe0
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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