Iodoethane → 5-Ethyl-7-methyl-5H,7H-isoxazolo[3,4-d]pyrimidine-4,6-dione

HRID 65918Notes

Reaction equation

HRID 65918 reaction equation
[CH3:1][N:2]1[C:7]2=[N:8][O:9][CH:10]=[C:6]2[C:5](=[O:11])[NH:4][C:3]1=[O:12].C(=O)([O-])[O-].[K+].[K+].[CH2:19](I)[CH3:20]>CN(C)C=O>[CH2:19]([N:4]1[C:5](=[O:11])[C:6]2=[CH:10][O:9][N:8]=[C:7]2[N:2]([CH3:1])[C:3]1=[O:12])[CH3:20]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 123806207-Methylisoxazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Product 1

HCID 123806275-Ethyl-7-methyl-5H,7H-isoxazolo[3,4-d]pyrimidine-4,6-dione

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 50 ml of dimethylformamide is dissolved 2 g of the 7-methyl-5H,7H-isoxazolo[3,4-d]pyrimidine-4,6-dione obtained in Example 19, followed by addition of 1.6 g of potassium carbonate and 2 ml of ethyl iodide. Then, the reaction and after-treatment are carried out in the same manner as Example 23 to obtain 0.9 g of the captioned compound as colorless crystals. melting point: 87°-88° C.

Workup

  1. customThen, the reaction

Sources & evidence

ORD record
ord-98d72dac1b174b2aa26bbefcff4156e1
Source dataset
uspto-grants-1978_12
Patent number
US04129654

Reaction notes

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