Toluene → 5-[(Trimethylsilyl)ethynyl]pyrimidine

HRID 667878Notes

Reaction equation

[Br:1][c:2]1[cH:3][n:4][cH:5][n:6][cH:7]1.[CH3:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:28][CH2:29][O:30][C:31](=[O:32])[CH3:33].[CH3:8][Si:9]([CH3:10])([CH3:11])[C:12]#[CH:13].[CH:21]([NH:22][CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[Cu:34][I:35]>>[c:2]1([C:13]#[C:12][Si:9]([CH3:8])([CH3:10])[CH3:11])[cH:3][n:4][cH:5][n:6][cH:7]1

Participants

Reactant 6

HCID 1140Toluene

HCID 7912Diisopropylamine

HCID 8857Ethyl Acetate

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 783445-Bromopyrimidine

Product 1

HCID 153496695-[(Trimethylsilyl)ethynyl]pyrimidine

Sources & evidence

ORD record: ord-8b0cd0bac6ec4a43aa20d3be308cb072
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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