HRID672518

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11

1,2-Dichloroethane

C2H4Cl2

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID65578

Ethanedioyl dichloride

C2Cl2O2

HCID81531

Diisopropylethylamine

C8H19N

HCID817122

4-Amino-3-fluoropyridine

C5H5FN2

HCID59313818

未命名化合物

HCID59313908

未命名化合物

HCID59624549

6,8-Dichloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

C12H6Cl2FN5O

PRODUCTS

生成物

HCID59624495

8-Bromo-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

C12H6BrClFN5O

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-49e6242b01a04745b27581d8fba141f9
来源数据集: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D
来源说明: Training data from https://doi.org/10.1039/C8SC04228D (3/10)

反应 SMILES

[Br:15][c:16]1[c:17]2[n:18]([n:19][c:20]([Cl:22])[cH:21]1)[c:23]([C:26](=[O:27])[OH:28])[cH:24][n:25]2.[CH:48]([N:49]([CH2:50][CH3:51])[CH:52]([CH3:53])[CH3:54])([CH3:55])[CH3:56].[Cl:1][c:2]1[cH:3][c:4]([Cl:5])[c:6]2[n:7]([c:8]([C:9]([OH:10])=[O:11])[cH:12][n:13]2)[n:14]1.[Cl:34][C:35]([C:36]([Cl:37])=[O:38])=[O:39].[Cl:57][c:58]1[cH:59][c:60]([Cl:61])[c:62]2[n:63]([c:64]([C:65]([NH:66][c:67]3[cH:68][cH:69][n:70][cH:71][c:72]3[F:73])=[O:74])[cH:75][n:76]2)[n:77]1.[Cl:78][CH2:79][CH2:80][Cl:81].[F:40][c:41]1[cH:42][n:43][cH:44][cH:45][c:46]1[NH2:47].[O:29]=[CH:30][N:31]([CH3:32])[CH3:33]>>[Br:15][c:16]1[c:17]2[n:18]([n:19][c:20]([Cl:22])[cH:21]1)[c:23]([C:26](=[O:28])[NH:47][c:46]1[c:41]([F:40])[cH:42][n:43][cH:44][cH:45]1)[cH:24][n:25]2