Water → ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate

HRID 678944Notes

Reaction equation

HRID 678944 reaction equation
[Br:1][c:2]1[c:3]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[n:4][c:5](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[s:6]1.[CH2:18]([C:19]#[CH:20])[O:21][CH:22]1[O:23][CH2:24][CH2:25][CH2:26][CH2:27]1.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cu:82][I:83].[OH2:35].[Pd:41]([Cl:42])[Cl:43].[c:44]1([P:45]([c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[cH:58][cH:59][cH:60][cH:61][cH:62]1.[c:63]1([P:64]([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[cH:77][cH:78][cH:79][cH:80][cH:81]1>>[c:2]1([C:20]#[C:19][CH2:18][O:21][CH:22]2[O:23][CH2:24][CH2:25][CH2:26][CH2:27]2)[c:3]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[n:4][c:5](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[s:6]1

Participants

9

Reactant 8

HCID 962WaterHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 98609Tetrahydro-2-(2-propynyloxy)-2H-pyranHCID 44558337Ethyl 5-bromo-2-phenylthiazole-4-carboxylate

Product 1

HCID 67425248ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate

Sources & evidence

ORD record
ord-5251722079fe4085b3ff90cc82cbe597
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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