Hydrochloric Acid → 1'-[1-[6-(Azetidin-1-yl)-3-pyridinyl]cyclopropanecarbonyl]spiro[furo[3,4-c]pyridine-1,3'-pyrrolidine]-3-one

HRID 691613Notes

Reaction equation

HRID 691613 reaction equation
[CH2:48]([Cl:49])[Cl:50].[CH3:33][C:34]1([CH3:35])[CH:36]2[CH2:37][CH2:38][C:39]1([CH2:40][S:41]([OH:42])(=[O:43])=[O:44])[C:45](=[O:46])[CH2:47]2.[CH3:60][CH2:61][O:62][C:63](=[O:64])[CH3:65].[CH:51]([N:52]([CH2:53][CH3:54])[CH:55]([CH3:56])[CH3:57])([CH3:58])[CH3:59].[ClH:1].[ClH:2].[N:3]1([c:7]2[cH:8][cH:9][c:10]([C:13]3([C:16](=[O:17])[Cl:18])[CH2:14][CH2:15]3)[cH:11][n:12]2)[CH2:4][CH2:5][CH2:6]1.[NH:19]1[CH2:20][C:21]2([O:22][C:23](=[O:30])[c:24]3[cH:25][n:26][cH:27][cH:28][c:29]32)[CH2:31][CH2:32]1>>[N:3]1([c:7]2[cH:8][cH:9][c:10]([C:13]3([C:16](=[O:17])[N:19]4[CH2:20][C:21]5([O:22][C:23](=[O:30])[c:24]6[cH:25][n:26][cH:27][cH:28][c:29]65)[CH2:31][CH2:32]4)[CH2:14][CH2:15]3)[cH:11][n:12]2)[CH2:4][CH2:5][CH2:6]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 81531DiisopropylethylamineHCID 666621763H-spiro[furo[3,4-c]pyridine-1,3'-pyrrolidin]-3-oneHCID 866022891-[6-(Azetidin-1-yl)-3-pyridinyl]cyclopropane-1-carbonyl chloride

Product 1

HCID 666622021'-[1-[6-(Azetidin-1-yl)-3-pyridinyl]cyclopropanecarbonyl]spiro[furo[3,4-c]pyridine-1,3'-pyrrolidine]-3-one

Sources & evidence

ORD record
ord-76924a5f5383449ba11ee331e58f41fd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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