Tetrahydrofuran → 5-Phenylethynyl-pyridin-2-ylamine

HRID 694538Notes

Reaction equation

HRID 694538 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[Cu:89][I:90].[NH2:1][c:2]1[n:3][cH:4][c:5]([I:8])[cH:6][cH:7]1.[Pd:48]([Cl:49])[Cl:50].[c:24]1([P:25]([c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41][cH:42]1.[c:51]1([P:52]([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[cH:65][cH:66][cH:67][cH:68][cH:69]1.[c:70]1([P:71]([c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[cH:84][cH:85][cH:86][cH:87][cH:88]1.[c:9]1([C:15]#[CH:16])[cH:10][cH:11][cH:12][cH:13][cH:14]1>>[NH2:1][c:2]1[n:3][cH:4][c:5]([C:16]#[C:15][c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 10821PhenylacetyleneHCID 11776Triphenylphosphine3×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 885792-Pyridinamine, 5-iodo-

Product 1

HCID 468541905-Phenylethynyl-pyridin-2-ylamine

Sources & evidence

ORD record
ord-35e8237411204ffe9cf924e637cdf853
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…