Hydrochloric Acid → 5-Chloro-7-morpholinothiazolo[4,5-d]pyrimidine-2-carbaldehyde

HRID 698251Notes

Reaction equation

HRID 698251 reaction equation
[CH3:17][Si:18]([N-:19][Si:20]([CH3:21])([CH3:22])[CH3:23])([CH3:24])[CH3:25].[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[n:8][cH:9][s:10]2.[ClH:32].[Li+:26].[O:27]=[CH:28][N:29]([CH3:30])[CH3:31].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[n:8][c:9]([CH:28]=[O:27])[s:10]2

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 576854145-Chloro-7-(morpholin-4-yl)[1,3]thiazolo[4,5-d]pyrimidine

Product 1

HCID 576853925-Chloro-7-morpholinothiazolo[4,5-d]pyrimidine-2-carbaldehyde

Sources & evidence

ORD record
ord-b394d04bfad5403a879c860cf9c66e15
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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