Chloride → 3'-(3-methoxy-3-methylbut-1-ynyl)-7'-pyridazin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine

HRID 699160Notes

Reaction equation

HRID 699160 reaction equation
[CH2:46]([Sn:47]([CH2:48][CH2:49][CH2:50][CH3:57])([c:51]1[cH:52][n:53][n:54][cH:55][cH:56]1)[CH2:58][CH2:59][CH2:60][CH3:61])[CH2:62][CH2:63][CH3:64].[Cl-:45].[Cu:65][I:66].[F:1][C:2]([F:3])([S:4]([O:5][c:17]1[cH:18][c:19]2[c:35]([cH:36][cH:37]1)[O:34][c:22]1[c:21]([cH:26][c:25]([C:27]#[C:28][C:29]([CH3:30])([CH3:31])[O:32][CH3:33])[cH:24][n:23]1)[C:20]21[N:38]=[C:39]([NH2:42])[O:40][CH2:41]1)(=[O:6])=[O:7])[C:8]([F:9])([F:10])[C:11]([F:12])([F:13])[C:14]([F:15])([F:16])[F:43].[Li+:44].[O:144]=[CH:145][N:146]([CH3:147])[CH3:148].[cH:67]1[cH:68][cH:69][c:70]([P:71]([Pd:72]([P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)([P:92]([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)([c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)[c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[P:111]([c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)([c:130]2[cH:131][cH:132][cH:133][cH:134][cH:135]2)[c:136]2[cH:137][cH:138][cH:139][cH:140][cH:141]2)[cH:142][cH:143]1>>[c:17]1(-[c:51]2[cH:52][n:53][n:54][cH:55][cH:56]2)[cH:18][c:19]2[c:35]([cH:36][cH:37]1)[O:34][c:22]1[c:21]([cH:26][c:25]([C:27]#[C:28][C:29]([CH3:30])([CH3:31])[O:32][CH3:33])[cH:24][n:23]1)[C:20]21[N:38]=[C:39]([NH2:42])[O:40][CH2:41]1

Participants

8

Reactant 7

HCID 312ChlorideHCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 28486Lithium ionHCID 64097334-(Tributylstannyl)pyridazineHCID 87381000[2-amino-3'-(3-methoxy-3-methylbut-1-ynyl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-7'-yl] 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonateHCID 178420554HCID 178420554, compound

Product 1

HCID 672423973'-(3-methoxy-3-methylbut-1-ynyl)-7'-pyridazin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine

Sources & evidence

ORD record
ord-dbe8869516374e4eb100c6345c580ff6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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