Hydrochloric Acid → Ethyl 4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-2-methoxypyrimidine-5-carboxylate
Reaction equation
[CH3:48][C:49]#[N:50].[CH3:51][CH2:52][O:53][C:54](=[O:55])[CH3:56].[CH:38]([N:39]([CH2:40][CH3:41])[CH:42]([CH3:43])[CH3:44])([CH3:45])[CH3:46].[Cl:16][c:17]1[c:18]([NH2:19])[cH:20][c:21]([O:26][CH2:27][c:28]2[c:29]([F:37])[c:30]([F:36])[cH:31][cH:32][c:33]2[O:34][CH3:35])[c:22]([O:24][CH3:25])[cH:23]1.[Cl:1][c:2]1[n:3][c:4]([O:13][CH3:14])[n:5][cH:6][c:7]1[C:8](=[O:9])[O:10][CH2:11][CH3:12].[ClH:15].[OH2:47]>>[c:2]1([NH:19][c:18]2[c:17]([Cl:16])[cH:23][c:22]([O:24][CH3:25])[c:21]([O:26][CH2:27][c:28]3[c:29]([F:37])[c:30]([F:36])[cH:31][cH:32][c:33]3[O:34][CH3:35])[cH:20]2)[n:3][c:4]([O:13][CH3:14])[n:5][cH:6][c:7]1[C:8](=[O:9])[O:10][CH2:11][CH3:12]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-710005ddae19440d8a4542033c645108
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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