Water → c-Met inhibitor 1

HRID 702066Notes

Reaction equation

HRID 702066 reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[CH3:1][n:2]1[n:3][cH:4][c:5](-[c:7]2[cH:8][cH:9][c:10]3[n:11]([n:12]2)[c:13]([SH:16])[n:14][n:15]3)[cH:6]1.[CH3:50][CH2:51][O:52][C:53](=[O:54])[CH3:55].[Cs+:41].[Cs+:42].[Cu:48][I:49].[I:17][c:18]1[cH:19][c:20]2[cH:21][n:22]([CH3:27])[n:23][c:24]2[cH:25][cH:26]1.[O:43]=[CH:44][N:45]([CH3:46])[CH3:47].[OH2:56].[n:28]1[cH:29][cH:30][cH:31][cH:32][c:33]1[C:34]([OH:35])=[O:36]>>[CH3:1][n:2]1[n:3][cH:4][c:5](-[c:7]2[cH:8][cH:9][c:10]3[n:11]([n:12]2)[c:13]([S:16][c:18]2[cH:19][c:20]4[cH:21][n:22]([CH3:27])[n:23][c:24]4[cH:25][cH:26]2)[n:14][n:15]3)[cH:6]1

Participants

10

Reactant 9

HCID 962WaterHCID 1018Picolinic acidHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 401540075-iodo-2-methyl-2H-indazoleHCID 178480034HCID 178480034, compound

Product 1

HCID 56650915c-Met inhibitor 1

Sources & evidence

ORD record
ord-5b7bbecaecd6459da7b837aee75cc08b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…