Sodium Carbonate → HCID 86706842, compound

HRID 707637Notes

Reaction equation

HRID 707637 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=O)=[CH:4][N:3]=1.Cl.[NH2:11][OH:12].C(=O)([O-])[O-].[Na+].[Na+].C(=O)(O)[O-].[Na+].C(=O)([O-])[O-].[K+].[K+]>O.C(O)C.CO>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[N:11][OH:12])=[CH:4][N:3]=1

Participants

9

Reactant 5

HCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 31609702-Methylpyrimidine-5-carbaldehyde

Product 1

HCID 86706842HCID 86706842, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

As per scheme-4, 2-methyl-pyrimidine-5-carbaldehyde (4-a) is reacted with hydroxylamine hydrochloride in the presence of base such as sodium carbonate or sodiumbicarbonate or potassium carbonate in a suitable solvent such as methanol or ethanol or water or mixture thereof, at a temperature ranging from 0° C. to 35° C., to provide corresponding 2-methyl-pyrimidine-5-carbaldehyde oxime (4-b).

Workup

  1. customranging from 0° C. to 35° C.

Sources & evidence

ORD record
ord-ba58cf9a874c41deb67fe1e3e54e363d
Source dataset
uspto-grants-2015_11
Patent number
US09175031B2

Reaction notes

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