Potassium Carbonate → HCID 58203803, compound
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6](I)[C:5]([O:9][CH2:10][CH2:11][C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C.[Cl-].C([N+](CC)(CC)CC)C.C(Cl)Cl.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:10][CH2:11][C:12]3[CH:16]=[CH:15][S:14][C:13]=3[C:6]=2[N:7]=1Participants
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 80 °C
Procedure
To a solution of 6-chloro-2-iodo-3-(2-(thiophen-3-yl)ethoxy)pyridine (9.14 g, 25.0 mmol) in acetonitrile (150 mL) was added tetraethylammonium chloride (4.14 g, 25.0 mmol), potassium carbonate (6.91 g, 50.0 mmol) and triphenylphosphine (1.31 g, 5.00 mmol) The reaction mixture was degassed and then charged with N2 three times. Palladium acetate (0.561 g, 2.50 mmol) was added to the reaction mixture. The reaction mixture was stirred under N2 at 80° C. for 3 h. The reaction mixture was diluted with DCM then filtered through celite. The filtrate was concentrated to get the crude product, which was purified by column on silica gel (EtOAc/Hexanes=1:10) to afford 54.6 g of 9-Chloro-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene (Yield: 89%)1H NMR (DMSO, 400 MHz): δ7.60 (d, J=5.2 Hz, 1H), 7.48 (d, J=6.0 Hz, 1H), 7.26 (d, J=6.0 Hz, 1H), 7.03 (d, J=5.2 Hz, 1H), 4.32 (t, J=4.4 Hz, 2H), 3.20 (t, J=4.4 Hz, 2H). LC-MS (ESI): m/z=238 [M+H]+
Workup
- customwas degassed
- additioncharged with N2 three times
- filtrationthen filtered through celite
- concentrationThe filtrate was concentrated
- customto get the crude product, which
- customwas purified by column on silica gel (EtOAc/Hexanes=1:10)
Sources & evidence
- ORD record
- ord-d7169d14c06245328d4d7d8cdf45bbc2
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09175009B2
Reaction notes
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