Hydrochloric Acid → HCID 178510370, compound

HRID 714445Notes

Reaction equation

HRID 714445 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:16]([C:17]#[N:18])=[CH:15][N:14]=[C:13]([S:19]C3C=CC=CC=3)[C:12]=2[C:26]#[N:27])=[CH:7][CH:6]=1.[S-2].[Na+].[Na+].Cl>CN(C=O)C>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:16]([C:17]#[N:18])=[CH:15][N:14]=[C:13]([SH:19])[C:12]=2[C:26]#[N:27])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14804Sodium SulfideHCID 66631608HCID 66631608, compound

Product 1

HCID 178510370HCID 178510370, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

0.1 g (0.268 mmol) of 4-[4-(2-hydroxyethoxy)phenyl]-2-(phenylthio)pyridine-3,5-dicarbonitrile (Example 47A) was initially charged in 1 ml of DMF. 73 mg (0.937 mmol) of sodium sulfide were added, and the mixture was then stirred at 80° C. for 2 h and stirred further at RT overnight. 20 ml of 1N hydrochloric acid were added, and the residue was filtered off and washed thoroughly with water.

Workup

  1. stirringstirred further at RT overnight
  2. filtrationthe residue was filtered off
  3. washwashed thoroughly with water

Sources & evidence

ORD record
ord-1fce76bba36b48b7a6037ab1f48e3407
Source dataset
uspto-grants-2015_11
Patent number
US09187428B2

Reaction notes

Loading…