Hydrochloric Acid → HCID 3738693, compound

HRID 715833Notes

Reaction equation

HRID 715833 reaction equation
[Br:1]Br.[CH3:3][C:4]12[CH2:14][CH:8]3[CH2:9][C:10]([CH3:13])([CH2:12][C:6]([C:15]([OH:17])=[O:16])([CH2:7]3)[CH2:5]1)[CH2:11]2.Cl.S([O-])([O-])=O.[Na+].[Na+]>[Fe].C(OCC)(=O)C>[Br:1][C:8]12[CH2:7][C:6]3([C:15]([OH:17])=[O:16])[CH2:12][C:10]([CH3:13])([CH2:11][C:4]([CH3:3])([CH2:5]3)[CH2:14]1)[CH2:9]2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 24408BromineHCID 24437Sodium SulfiteHCID 27362243,5-Dimethyladamantane-1-carboxylic acid

Product 1

HCID 3738693HCID 3738693, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

In a 50 mL round-bottomed flask, bromine (3 mL) was cooled to 0° C. and iron (0.56 g) was added. The mixture was stirred at 0° C. for 30 minutes. 3,5-Dimethyladamantane-1-carboxylic acid (0.5 g) was added. The mixture was stirred at room temperature overnight. After adding ice and 6N aqueous HCl (10 mL), ethyl acetate (20 mL), and saturated aqueous sodium sulfite were added. The aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with saturated sodium sulfite and dried over sodium sulfate. After filtration and removal of the solvent, the product was used directly in the next step.

Workup

  1. stirringThe mixture was stirred at room temperature overnight
  2. additionwere added
  3. extractionThe aqueous layer was extracted twice with ethyl acetate
  4. washThe combined organic layers were washed with saturated sodium sulfite
  5. dry with materialdried over sodium sulfate
  6. filtrationAfter filtration and removal of the solvent

Sources & evidence

ORD record
ord-40104fb1a1d9479288e937ffcf4394dd
Source dataset
uspto-grants-2015_11
Patent number
US09187472B2

Reaction notes

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