4-Methylmorpholine → 2-[2-[2-Ethyl-4-(1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)piperazin-1-yl]-(4-chlorobenzyl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 720189Notes

Reaction equation

HRID 720189 reaction equation
[ClH:1].[NH2:2][CH:3](CC1C=CC(Cl)=CC=1)[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH:12]([CH2:17][C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=2)[C:13]([NH:15][CH3:16])=[O:14])[CH2:8][CH:7]1[CH2:28][CH3:29])=[O:5].[C:38]([N:45]1[CH2:52][CH2:51][CH2:50][C@H:46]1[C:47]([OH:49])=O)([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39].[CH3:53]N(C)CCCN=C=NCC.ON1[C:69]2[CH:70]=[CH:71][CH:72]=[CH:73][C:68]=2N=N1.CN1CCOCC1>CN(C=O)C.O.CCOC(C)=O>[C:41]([O:40][C:38]([N:45]1[CH2:52][CH2:51][CH2:50][CH:46]1[C:47](=[O:49])[N:2]([CH2:53][C:68]1[CH:73]=[CH:72][C:71]([Cl:1])=[CH:70][CH:69]=1)[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH:12]([C:13](=[O:14])[NH:15][CH3:16])[CH2:17][C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=2)[CH2:8][CH:7]1[CH2:28][CH3:29])=[O:5])=[O:39])([CH3:42])([CH3:43])[CH3:44]

Participants

9

Reactant 5

HCID 79724-MethylmorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 695874692-{4-[2-amino-3-(4-chlorophenyl)-propionyl]-3-ethyl-piperazin-1-yl}-N-methyl-3-naphthalen-2-yl-propioamide HCl

Product 1

HCID 695879212-[2-[2-Ethyl-4-(1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)piperazin-1-yl]-(4-chlorobenzyl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

2-{4-[2-Amino-3-(4-chlorophenyl)-propionyl]-3-ethyl-piperazin-1-yl}-N-methyl-3-naphthalen-2-yl-propioamide HCl, 45, (0.5 g, 0.7 mmol) and Boc-L-proline (0.17 g, 0.78 mmol), 1-(3-dimethylamino-propyl)-3-ethylcarbodiimide (0.19 g, 1.4 mmol) and 1-hydroxybenzotriazole (0.16 g, 0.86 mmol) are dissolved in anhydrous DMF (2.5 mL). The reaction mixture is cooled to 0° C., then N-methylmorpholine (0.6 mL, 5.3 mmol) is added. This reaction mixture is placed in a refrigerator overnight. EtOAc (25 mL) and water (75 mL) are added, and the organic layer is separated. The aqueous layer is extracted with EtOAc (3×30 mL). All organic layers are combined and washed with water (2×50 mL), and dried over Na2SO4. Solvent is removed in vacuo to afford 0.5 g of the desired product.

Workup

  1. customis placed in a refrigerator overnight
  2. customthe organic layer is separated
  3. extractionThe aqueous layer is extracted with EtOAc (3×30 mL)
  4. washwashed with water (2×50 mL)
  5. dry with materialdried over Na2SO4
  6. customSolvent is removed in vacuo

Sources & evidence

ORD record
ord-12140260d8bd4c5ca226870f112ac7bb
Source dataset
uspto-grants-2006_11
Patent number
US07132539B2

Reaction notes

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