Hydrochloric Acid → HCID 178474088, compound

HRID 720464Notes

Reaction equation

HRID 720464 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=2)[C:5]([C:20]#[N:21])=[C:4]([S:22]C2C=CC=CC=2)[N:3]=1.[S-2].[Na+].[Na+].Cl>CN(C=O)C>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:14][CH:15]=2)[C:5]([C:20]#[N:21])=[C:4]([SH:22])[N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14804Sodium SulfideHCID 12016387N-{4-[2-Amino-3,5-dicyano-6-(phenylsulphanyl)-4-pyridinyl]phenyl}acetamide

Product 1

HCID 178474088HCID 178474088, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Under argon, 1.16 g (3 mmol) of N-{4-[2-amino-3,5-dicyano-6-(phenylsulfanyl)-4-pyridinyl]phenyl}-acetamide are dissolved in 10 ml of DMF, 0.78 g (10 mmol) of sodium sulfide are added and the mixture is stirred at 80° C. for 2 h. 20 ml of 1N HCl are then added and the resulting crystals are filtered off with suction and dried under reduced pressure.

Workup

  1. filtrationthe resulting crystals are filtered off with suction
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-2398b58de3f04f3cb6df7b032dad8cda
Source dataset
uspto-grants-2006_11
Patent number
US07135486B1

Reaction notes

Loading…