反应详情

温度

160 °C

7-Bromo-1-cyclohexylimidazo[1,5-a]quinoxalin-4 (5H)-one as synthesized in above Example 145, 200 mg, pyrazole 59 mg, potassium carbonate 120 mg, copper iodide 28 mg and N,N-dimethylformamide 4 mL were mixed and stirred for 22 hours at 160° C. The reaction liquid was poured into water, and the precipitated matter was recovered by filtration. The precipitate was mixed with 25% aqueous ammonia and methanol, and heated under stirring. The insoluble matter was recovered by filtration, washed with water and dried by heating under reduced pressure to provide 30 mg of the title compound.

1. additionwere mixed
2. customThe reaction liquid
3. filtrationthe precipitated matter was recovered by filtration
4. additionThe precipitate was mixed with 25% aqueous ammonia and methanol
5. temperatureheated
6. stirringunder stirring
7. filtrationThe insoluble matter was recovered by filtration
8. washwashed with water
9. customdried
10. temperatureby heating under reduced pressure