Hydrochloric Acid → HCID 24864087, compound

HRID 729456Notes

Reaction equation

HRID 729456 reaction equation
[Br:1][C:2]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]3[N:21]([CH2:22][C:23]([O:25]CC)=[O:24])[N:20]=[N:19][N:18]=3)=[N:15][CH:16]=2)[CH2:7][CH2:6]1.CO.[OH-].[Na+].Cl>C1COCC1.C(OCC)(=O)C>[Br:1][C:2]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]3[N:21]([CH2:22][C:23]([OH:25])=[O:24])[N:20]=[N:19][N:18]=3)=[N:15][CH:16]=2)[CH2:7][CH2:6]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 86621800HCID 86621800, compound

Product 1

HCID 24864087HCID 24864087, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate (Isomer A) from Step 7 (0.067 g, 0,132 mmol) in THF (2 mL) and MeOH (2 mL) was added 1 N NaOH (2 mL). After approximately 2 h, ethyl acetate and 1 N HCl were added to the reaction mixture. The organic phase was separated, dried over sodium sulfate and evaporated to give the title compound.

Workup

  1. customThe organic phase was separated
  2. dry with materialdried over sodium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-af721b1c85514951adc4db36632929da
Source dataset
uspto-grants-2009_09
Patent number
US07582633B2

Reaction notes

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