反应详情

The [5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetyl chloride is reacted with 3-(3-amino-phenyl)-2H-[1,2,4]oxadiazol-5-one, a known compound or compound prepared by known methods, wherein the 3-(3-amino-phenyl)-2H-[1,2,4]oxadiazol-5-one may be present as a free base or, for example, as its corresponding HCl salt; in the presence of an organic base such as TEA, DIPEA, pyridine, and the like, preferably DIPEA; wherein the base is preferably present in an amount from about 1 to about 2 equivalents; in an aprotic organic solvent such as acetonitrile, toluene, THF, MTBE, and the like, preferably acetonitrile; to yield the 2-[5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-N-[3-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-acetamide, the compound of formula (Is).

1. customa known compound or compound prepared