Thioglycolic Acid → HCID 22413933, compound

HRID 731949Notes

Reaction equation

HRID 731949 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[N+]([C:15]1C=CC=CC=1S(Cl)(=O)=O)([O-])=O.IC.C(=O)([O-])[O-].[K+].[K+].C(O)(=O)CS>C(N(CC)CC)C>[CH3:15][NH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

7

Reactant 5

HCID 1133Thioglycolic AcidHCID 6328Methyl iodideHCID 7604m-AminoacetanilideHCID 11430Potassium CarbonateHCID 155402-Nitrobenzenesulfonyl chloride

Product 1

HCID 22413933HCID 22413933, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

N-(3-Aminophenyl)acetamide was treated with 2-nitrophenylsulfonyl chloride in the presence of triethylamine and then the resulting compound was treated with iodomethane and potassium carbonate. Thereafter, the product was treated with thioglycolic acid to obtain N-[3-(methylamino)phenyl]acetamide.

Sources & evidence

ORD record
ord-32a054b2c9294b6797ba465de0d4ec3e
Source dataset
uspto-grants-2009_09
Patent number
US07585878B2

Reaction notes

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