Potassium Carbonate → HCID 23104613, compound

HRID 734147Notes

Reaction equation

HRID 734147 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].[OH:12][CH:13]([CH2:16][OH:17])[CH2:14][NH2:15].C([O-])([O-])=O.[K+].[K+]>CN1CCCC1=O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:15][CH2:14][CH:13]([OH:12])[CH2:16][OH:17])=[C:3]([CH3:11])[CH:4]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 735613-Amino-1,2-propanediol

Product 1

HCID 23104613HCID 23104613, compoundYield 68.6%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
60 °C

Procedure

2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.4 g of 2,3-dihydroxy-1-propylamine, and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 15 hours and, after cooling to room temperature, was poured into a water/ice mixture. A yellow precipitate formed, which was filtered off, reslurried in water and then dried over P2O5. 2 g of 3-(4-nitro-2-methylphenylamino)propane-1,2-diol (7) were obtained.

Workup

  1. temperatureafter cooling to room temperature
  2. customA yellow precipitate formed
  3. filtrationwhich was filtered off
  4. dry with materialdried over P2O5

Sources & evidence

ORD record
ord-0b6eefbb3b8f4a58aedef35e88d93df0
Source dataset
uspto-grants-2009_09
Patent number
US07591860B2

Reaction notes

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