反应详情

温度

110 °C

(2-Fluoro-3-trifluoromethyl-phenyl)-(4-fluoro-phenyl)-methanone (6.58 g, 23 mmol) was dissolved in 20 ml of pyridine. Hydrazine hydrate (7.36 mL, 230 mmol) and 4-(dimethylamino)-pyridine (2.8 g, 23 mmol) were added. The reaction mixture was stirred overnight at 110° C. After cooling to room temperature, EtOAc and 2N HCl were added. The organic phase was washed three times with brine, dried over NaSO4 and concentrated under vacuum. Purification of the crude product by plug filtration (silica gel, CH2Cl2) provided 5.18 g product as a white solid.

1. temperatureAfter cooling to room temperature
2. washThe organic phase was washed three times with brine
3. dry with materialdried over NaSO4
4. concentrationconcentrated under vacuum
5. customPurification of the crude product
6. filtrationby plug filtration (silica gel, CH2Cl2)