反应详情

温度

70 °C

67.6 g (0.43 mol) 3-Methoxycarbonyl-5-hydroxy-1-methylpyrazole and 299.2 g (2.17 mol) potassium carbonate were dissolved in 1500 ml dimethylformamide and warmed to 70° C. At this temperature, chloro-difluoromethane was passed through for 2 hours and then stirred for 1.5 hours at 80° C. The reaction mixture was added to water and shaken 6 times with ethyl acetate. The combined organic phases were washed with saturated sodium chloride and dried over magnesium sulfate. The reaction solution was concentrated.

1. customwas passed through for 2 hours
2. washThe combined organic phases were washed with saturated sodium chloride
3. dry with materialdried over magnesium sulfate
4. concentrationThe reaction solution was concentrated