反应详情

温度

50 °C

5.85 g (29 mmol) of t-butyl(2-bromoethyl)carbamate was dissolved in 100 ml of dimethylformamide. 2.38 g (26.4 mmol) of 3-hydroxybenzonitrile, 3.04 g (53 mmol) of potassium carbonate and 4.31 g (53 mmol) of sodium iodide were added to the solution, and the obtained mixture was stirred at 50° C. for 6 hours. After the treatment with ethyl acetate as the extractant in an ordinary manner, the crude product was obtained. After the purification by silica gel column chromatography, the title compound was obtained.

1. customAfter the purification by silica gel column chromatography