Tributylamine → HCID 86760712, compound

HRID 747759Notes

Reaction equation

HRID 747759 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C@H:25]([NH:36][S:37]([C:40]3[CH:45]=[CH:44][C:43](I)=[CH:42][CH:41]=3)(=[O:39])=[O:38])[CH2:26][O:27][C:28]3[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=3)[C:31]#[N:32])=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:47]([O:51][CH2:52][CH3:53])(=[O:50])[CH:48]=[CH2:49].C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(N(CCCC)CCCC)CCC>C(#N)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.ClCCl>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C@H:25]([NH:36][S:37]([C:40]3[CH:45]=[CH:44][C:43](/[CH:49]=[CH:48]/[C:47]([O:51][CH2:52][CH3:53])=[O:50])=[CH:42][CH:41]=3)(=[O:39])=[O:38])[CH2:26][O:27][C:28]3[CH:35]=[CH:34][CH:33]=[C:30]([C:31]#[N:32])[CH:29]=3)=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

8

Reactant 4

HCID 7622TributylamineHCID 8821Ethyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 68830378HCID 68830378, compound

Product 1

HCID 86760712HCID 86760712, compound

Reagents, catalysts & solvents 3

HCID 167845palladium(II) acetateCatalystHCID 6342AcetonitrileSolventHCID 6344DichloromethaneSolvent

Procedure

738 mg (1.00 mmol)) of 3-[(2S)-3-[4-[1-(benzyloxycarbonyl)-4-piperidyloxy]phenyl]-2-(4-iodobenzenesulfonylamino)propoxy]benzonitrile was dissolved in 5 ml of acetonitrile. 0.22 ml (2.0 mmol) of ethyl acrylate, 11 mg (0.05 mmol) of palladium acetate, 91 mg (0.3 mmol) of tris-o-tolylphosphine and 0.48 ml (2.0 mmol) of tributylamine were added to the solution, and they were heated under reflux for 15 hours. After the same isolation process as that of step 1 in Example 1 with dichloromethane as the extractant, the crude product was obtained, which was purified by the silica gel column chromatography to obtain the title compound.

Workup

  1. temperaturewere heated
  2. temperatureunder reflux for 15 hours
  3. customwhich was purified by the silica gel column chromatography

Sources & evidence

ORD record
ord-a99ecdb2533a474dade974fc8788f1d9
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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