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HRID748610

反应详情

EQUATION

反应方程式

HRID 748610 的结构方程式

REACTANTS

反应物

7
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CC(=O)c1ccccn1
HCID14286

1-(2-Pyridyl)-1-ethanone

C7H7NO

结构：N#Cc1ccc(CBr)cc1
HCID86996

Benzonitrile, 4-(bromomethyl)-

C8H6BrN

结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CCOCC.Cl
HCID10953452

未命名化合物

结构：CC(C)(C)OC(=O)NCCNCCNC(=O)OC(C)(C)C
HCID15157893

Di-tert-butyl [azanediyldi(ethane-2,1-diyl)]biscarbamate

C14H29N3O4

结构：Cc1ccc(C#N)c(N(CCNC(=O)OC(C)(C)C)CCNC(=O)OC(C)(C)C)c1
HCID69032449

未命名化合物

PRODUCTS

生成物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O=Cc1ccccn1
HCID14273

2-Pyridinecarboxaldehyde

C6H5NO

结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

A mixture of bis(2-tert-butoxycarbonylaminoethyl)amine (0.01 mol), 4-cyanobenzyl-bromide (0.01 mol), K2CO3 (0.05 mol), and CH3CN (70 mL) was heated at 60° C. for 10 hours. The resultant bis(2-tert-butoxycarbonylaminoethyl)amino-4-methylphenylcyanide was deprotected using HCl/ether, condensed with 2-acetyl pyridine (0.01 mol) in MeOH, and then reduced by NaBH4. After sequential treatments with pyridine-2-carboxaldehyde, NaBH4, and HCl, compound 110 was obtained in 75% overall yield.