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HRID75029

反应详情

EQUATION

反应方程式

HRID 75029 的结构方程式

REACTANTS

反应物

7
结构：O=P([O-])([O-])[O-].[K+].[K+].[K+]
HCID62657

Tripotassium phosphate

K3O4P

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1
HCID11155794

2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl

C33H49P

结构：C1CCOC1.O
HCID21881883

Oxolane--water (1/1)

C4H10O2

结构：Cc1ccc(S(=O)(=O)n2cc(B3OC(C)(C)C(C)(C)O3)c3cc(Cl)cnc32)cc1
HCID57597747

5-Chloro-1-(4-methylbenzene-1-sulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

C20H22BClN2O4S

2 次

结构：Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(S(C)=O)n3)c3cc(Cl)cnc32)cc1
HCID67285321

未命名化合物

3 次

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]1(C(=O)O)CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)[C@H]1O
HCID68008179

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

6
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：O
溶剂HCID962

Water

H2O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Pd/C (wet, Degussa), hydrogen, EtOH; (b) 2,4-dichloro-5-fluoropyrimidine, iPr2NEt, THF, reflux; (c) LiOH, THF/water, 50° C.; (d) DPPA, Et3N, THF, 85° C.; (e) 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine, XPhos, Pd2(dba)3, K3PO4, 2-methyl THF, water, 125° C.; (f)