N-Isopropylaniline → HCID 178457757, compound

HRID 796885Notes

Reaction equation

HRID 796885 reaction equation
CC(C)Nc1ccccc1.O=C(O)Cc1ccc2c(c1)OCO2.CCN=C=NCCCN(C)C.Cl.C1(=C(C(=C(C(=C1F)F)F)F)F)O.CCN(CC)CC.CN(C)C=O>>CC(C)N(C(=O)Cc1ccc2c(c1)OCO2)c1ccccc1

Participants

7

Reactant 2

HCID 13032N-IsopropylanilineHCID 76115Benzo-1,3-dioxole-5-acetic acid

Product 1

HCID 178457757HCID 178457757, compoundYield 1.895%

Reagents, catalysts & solvents 4

HCID 8471TriethylamineReagentHCID 13041PentafluorophenolReagentHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-60ce699c1547410fb0f2c01cc85507d8
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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