1,2-Dibromoethane → 1-(1-Phenylcyclohexyl)-4-hydroxypiperidine

HRID 800228Notes

Reaction equation

HRID 800228 reaction equation
[Br:10][CH2:11][CH2:12][Br:13].[Br:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[C:14](#[N:15])[C:16]1([N:22]2[CH2:23][CH2:24][CH:25]([OH:28])[CH2:26][CH2:27]2)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1.[I:9].[Mg:8].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[c:2]1([C:16]2([N:22]3[CH2:23][CH2:24][CH:25]([OH:28])[CH2:26][CH2:27]3)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 78391,2-DibromoethaneHCID 7961BromobenzeneHCID 8028TetrahydrofuranHCID 24841Hydrogen iodideHCID 5462224MagnesiumHCID 100589041-(4-Hydroxypiperidin-1-yl)cyclohexane-1-carbonitrile

Product 1

HCID 988401-(1-Phenylcyclohexyl)-4-hydroxypiperidine

Sources & evidence

ORD record
ord-fa2f247dad134e689779ffabdb099de2
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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