Acetate → 1-(5-Methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-one
Reaction equation
[CH2:21]([N:22]([CH2:23][CH3:24])[CH2:25][CH3:26])[CH3:27].[CH2:2]([O:3][C:4](=[O:5])[C:8]1=[C:13]([OH:14])[CH2:12][CH2:11][N:10]([c:15]2[o:16][c:17]([CH3:20])[n:18][n:19]2)[CH2:9]1)[CH:6]=[CH2:7].[CH:28]([OH:29])=[O:30].[ClH:50].[K:1].[O-:57][C:58]([CH3:59])=[O:60].[O-:61][C:62]([CH3:63])=[O:64].[O:51]1[CH2:52][CH2:53][CH2:54][CH2:55]1.[Pd+2:56].[c:31]1([P:32]([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[cH:45][cH:46][cH:47][cH:48][cH:49]1>>[CH2:8]1[CH2:9][N:10]([c:15]2[o:16][c:17]([CH3:20])[n:18][n:19]2)[CH2:11][CH2:12][C:13]1=[O:14]Participants
10
Reactant 9
HCID 175Acetate2×
HCID 284Formic Acid
HCID 313Hydrochloric Acid
HCID 8028Tetrahydrofuran
HCID 8471Triethylamine
HCID 11776Triphenylphosphine
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 5462222Potassium
HCID 67341974prop-2-enyl 4-hydroxy-1-(5-methyl-1,3,4-oxadiazol-2-yl)-3,6-dihydro-2H-pyridine-5-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-8b1846bcfa374e65b09a468fcdd93729
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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