1,2-Dichloroethane → Hydrochloric Acid

HRID 801592Notes

Reaction equation

HRID 801592 reaction equation
[C:36]([O:37][BH-:38]([O:39][C:40](=[O:41])[CH3:42])[O:43][C:44](=[O:45])[CH3:46])(=[O:47])[CH3:48].[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[CH:2]1([c:5]2[cH:6][c:7]([F:21])[c:8]3[c:9]([n:10]([CH:14]4[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]4)[c:11](=[O:13])[nH:12]3)[cH:20]2)[CH2:3][CH2:4]1.[Cl:50][CH2:51][CH2:52][Cl:53].[ClH:1].[Na+:49].[O:29]1[CH2:30][CH2:31][C:32](=[O:35])[CH2:33][CH2:34]1>>[CH:2]1([c:5]2[cH:6][c:7]([F:21])[c:8]3[c:9]([n:10]([CH:14]4[CH2:15][CH2:16][N:17]([CH:32]5[CH2:31][CH2:30][O:29][CH2:34][CH2:33]5)[CH2:18][CH2:19]4)[c:11](=[O:13])[nH:12]3)[cH:20]2)[CH2:3][CH2:4]1.[ClH:1]

Participants

9

Reactant 7

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 923Sodium ionHCID 8471TriethylamineHCID 121599Tetrahydro-4H-pyran-4-oneHCID 2724942TriacetoxyborohydrideHCID 596832826-cyclopropyl-4-fluoro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

Product 2

HCID 313Hydrochloric AcidHCID 160692146-cyclopropyl-4-fluoro-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

Sources & evidence

ORD record
ord-6afdbe9e041b486da60e1ef8037fe47c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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