Hydrochloric Acid → propan-2-yl 3-[[2-(1-acetyl-3-oxo-5-phenyl-2-propan-2-yl-2H-pyrazin-4-yl)acetyl]amino]-2-hydroxy-4-phenylbutanoate

HRID 803528Notes

Reaction equation

HRID 803528 reaction equation
[C:35]([CH3:36])(=[O:37])[N:38]1[CH:39]([CH:55]([CH3:56])[CH3:57])[C:40](=[O:54])[N:41]([CH2:50][C:51](=[O:52])[OH:53])[C:42]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)=[CH:43]1.[CH2:70]([Cl:71])[Cl:72].[CH3:1][N:2]1[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1.[CH3:59][N:60]([CH3:61])[CH2:62][CH2:63][CH2:64][N:65]=[C:66]=[N:67][CH2:68][CH3:69].[CH3:73][CH2:74][O:75][C:76](=[O:77])[CH3:78].[ClH:58].[NH2:18][CH:19]([CH:20]([C:21](=[O:22])[O:23][CH:24]([CH3:25])[CH3:26])[OH:27])[CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[OH:8][n:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[n:16][n:17]1>>[NH:18]([CH:19]([CH:20]([C:21](=[O:22])[O:23][CH:24]([CH3:25])[CH3:26])[OH:27])[CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[C:51]([CH2:50][N:41]1[C:40](=[O:54])[CH:39]([CH:55]([CH3:56])[CH3:57])[N:38]([C:35]([CH3:36])=[O:37])[CH:43]=[C:42]1[c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)=[O:52]

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 79724-MethylmorpholineHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 14604123Propan-2-yl 3-amino-2-hydroxy-4-phenylbutanoateHCID 22284314{(3RS)-4-Acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetic acid

Product 1

HCID 21302836propan-2-yl 3-[[2-(1-acetyl-3-oxo-5-phenyl-2-propan-2-yl-2H-pyrazin-4-yl)acetyl]amino]-2-hydroxy-4-phenylbutanoate

Sources & evidence

ORD record
ord-c2241c2c35ff4e2dbd9c20e587400956
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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