Bicarbonate Ion → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-[3-(2-oxo-1-imidazolidinyl)-1-propynyl]-3-hydroxy-3-(2-chlorophenyl)oxindole
Reaction equation
[CH2:103]1[O:104][CH2:105][CH2:106][CH2:107]1.[CH2:1]([CH3:2])[N:3]([CH2:4][CH2:5][N:6]1[C:7](=[O:28])[C:8]([c:20]2[c:21]([Cl:26])[cH:22][cH:23][cH:24][cH:25]2)([OH:27])[c:9]2[c:10]([C:16]([F:17])([F:18])[F:19])[cH:11][c:12]([I:15])[cH:13][c:14]21)[CH2:29][CH3:30].[CH3:40][CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46].[CH3:96][c:97]1[cH:98][cH:99][cH:100][cH:101][cH:102]1.[Cu:52][I:53].[Na+:51].[O-:47][C:48]([OH:49])=[O:50].[O:31]=[C:32]1[N:33]([CH2:37][C:38]#[CH:39])[CH2:34][CH2:35][NH:36]1.[OH2:95].[Pd:54]([Cl:55])[Cl:56].[c:57]1([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[cH:71][cH:72][cH:73][cH:74][cH:75]1.[c:76]1([P:77]([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[cH:90][cH:91][cH:92][cH:93][cH:94]1>>[CH2:1]([CH3:2])[N:3]([CH2:4][CH2:5][N:6]1[C:7](=[O:28])[C:8]([c:20]2[c:21]([Cl:26])[cH:22][cH:23][cH:24][cH:25]2)([OH:27])[c:9]2[c:10]([C:16]([F:17])([F:18])[F:19])[cH:11][c:12]([C:39]#[C:38][CH2:37][N:33]3[C:32](=[O:31])[NH:36][CH2:35][CH2:34]3)[cH:13][c:14]21)[CH2:29][CH3:30]Participants
12
Reactant 11
HCID 769Bicarbonate Ion
HCID 923Sodium ion
HCID 962Water
HCID 1140Toluene
HCID 8028Tetrahydrofuran
HCID 8471Triethylamine
HCID 11776Triphenylphosphine2×
HCID 24290Palladium Chloride
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 129902161-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-chlorophenyl)oxindole
HCID 156696571-(Prop-2-yn-1-yl)imidazolidin-2-oneProduct 1
Sources & evidence
- ORD record
- ord-b120c13298f349669d22c2ab06469a4b
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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